188Re radiopharmaceuticals for radiosynovectomy: evaluation and comparison of tin colloid, hydroxyapatite and tin-ferric hydroxide macroaggregates

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188Re radiopharmaceuticals for radiosynovectomy: evaluation and comparison of tin colloid, hydroxyapatite and tin-ferric hydroxide macroaggregates

BACKGROUND: Radiosynovectomy is a therapy used to relieve pain and inflammation from rheumatoid arthritis and related diseases. In this study three 188Re particulate compounds were characterized according to their physico-chemical properties and their biological behavior in rabbits. The results were compared in order to establish which was the radiopharmaceutical that better fits the requiremen...

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90Y ferric hydroxide colloid.

At the Radiochemical Centre we have recently developed a new 90Y colloid which has greater stability than the currently available 90Y silicate colloid and appears from the results of animal tests to be suitable for the treatment of rheumatoid knee joint effusions. In this report the need for a new 90Y colloid is assessed and the preparation and properties of the new colloid are described. Curre...

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Comparison of 90Y ferric hydroxide colloid with the citrate and resin colloids. A preliminary animal study.

This was a preliminary evaluation of 90Y ferric hydroxide colloid for the Radiochemical Centre before using it in patients. Autoradiographs of rabbit knees, both inflamed and non-inflamed, showed that the material was evenly distributed in the synovium, and that there was no evidence of aggregation in vivo. Table I shows the retention of ferric hydroxide colloid in the knees of nine rabbits kil...

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ژورنال

عنوان ژورنال: BMC Nuclear Medicine

سال: 2004

ISSN: 1471-2385

DOI: 10.1186/1471-2385-4-1